The role of NOD1/CARD4 and NOD2/CARD15 genetic variations in lung cancer risk

Ozbayer C. , Kurt H., Bayramoglu A., Gunes H. V. , Metintas M., Degirmenci I. , ...Daha Fazla

INFLAMMATION RESEARCH, cilt.64, ss.775-779, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 64
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s00011-015-0859-0
  • Sayfa Sayıları: ss.775-779


Background and aim NOD1/CARD4 and NOD2/CARD15 are members of the Nod-like receptor (NLR) family, and they contain a caspase recruitment domain (CARD). NLRs are located in the cytosol where they bind bacterial and viral ligands and play a key role in the innate and adaptive immune response, apoptosis, autophagy, and reactive oxygen species generation. NLR gene polymorphisms may shift the balance between pro- and anti-inflammatory cytokines and modulate the risk of infection, chronic inflammation, and cancer. NOD1/CARD4 and NOD2/CARD15 gene polymorphisms may also be associated with altered risks for many cancer types. The aim of our study was to evaluate the potential associations between lung cancer and NOD1/CARD4 and NOD2/CARD15 polymorphisms.