The role of NOD1/CARD4 and NOD2/CARD15 genetic variations in lung cancer risk


Ozbayer C., Kurt H., Bayramoglu A., Gunes H. V. , Metintas M., Degirmenci I., ...More

INFLAMMATION RESEARCH, vol.64, no.10, pp.775-779, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 10
  • Publication Date: 2015
  • Doi Number: 10.1007/s00011-015-0859-0
  • Journal Name: INFLAMMATION RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.775-779
  • Keywords: Lung cancer, Inflammation, NOD1/CARD4, NOD2/CARD15, Polymorphism, INNATE IMMUNITY GENES, NOD-LIKE RECEPTORS, INFLAMMATION, SUSCEPTIBILITY, POLYMORPHISMS, ASSOCIATION, DISEASE, PROTEINS, CARD4
  • Kütahya Health Sciences University Affiliated: No

Abstract

Background and aim NOD1/CARD4 and NOD2/CARD15 are members of the Nod-like receptor (NLR) family, and they contain a caspase recruitment domain (CARD). NLRs are located in the cytosol where they bind bacterial and viral ligands and play a key role in the innate and adaptive immune response, apoptosis, autophagy, and reactive oxygen species generation. NLR gene polymorphisms may shift the balance between pro- and anti-inflammatory cytokines and modulate the risk of infection, chronic inflammation, and cancer. NOD1/CARD4 and NOD2/CARD15 gene polymorphisms may also be associated with altered risks for many cancer types. The aim of our study was to evaluate the potential associations between lung cancer and NOD1/CARD4 and NOD2/CARD15 polymorphisms.