Methotrexate toxicity presenting as cutaneous ulcerations on psoriatic plaques

Koçak A., Koçak O. , Aslan F. , Tektaş M.

Cutaneous and Ocular Toxicology, vol.32, no.4, pp.333-335, 2013 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 4
  • Publication Date: 2013
  • Doi Number: 10.3109/15569527.2013.779278
  • Title of Journal : Cutaneous and Ocular Toxicology
  • Page Numbers: pp.333-335
  • Keywords: Cutaneous ulceration, Methotrexate, Toxicity


Methotrexate (MTX) is an effective but potentially toxic treatment for psoriasis. We describe a patient who administered 20mg daily of MTX for 5d and presented with ulcerated and necrotic lesions on the psoriatic plaques, mouth erosions and hair loss. However, his psoriatic plaques and ulcerations totally healed rapidly within two weeks and no recurrence has been observed for the 6 months of follow up. © 2013 Informa Healthcare USA, Inc.