Enhancement of vascular endothelial growth factor's angiogenic capacity by the therapeutic modulation of notch signalling improves tram flap survival in rats submitted to nicotine


ABBAS O. L. , TERZİ Y. K. , ÖZATİK O. , ÖZATİK F. Y. , Turna G., Nar R., ...More

JOURNAL OF PLASTIC SURGERY AND HAND SURGERY, vol.51, no.6, pp.405-413, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.1080/2000656x.2017.1285784
  • Title of Journal : JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
  • Page Numbers: pp.405-413
  • Keywords: Notch, Dll4, TRAM, nicotine, survival, angiogenesis, DONOR-SITE COMPLICATIONS, PATTERN SKIN FLAPS, BREAST RECONSTRUCTION, TUMOR ANGIOGENESIS, CIGARETTE-SMOKING, GENE-THERAPY, BLOOD-FLOW, VIABILITY, MODEL, VEGF

Abstract

Background: Smoke of cigarettes, and specifically nicotine, has been shown to diminish pedicled transverse rectus abdominis musculocutaneous (TRAM) flap survival. Considering that Notch signalling through its ligand Delta-like 4 (Dll4) functions as anti-angiogenic factor by inhibiting the pro-angiogenic effects of vascular endothelial growth factor (VEGF), it is hypothesised that inhibition of the Notch would promote angiogenesis and increase TRAM flap survival in rats submitted to nicotine.