Enhancement of vascular endothelial growth factor's angiogenic capacity by the therapeutic modulation of notch signalling improves tram flap survival in rats submitted to nicotine

ABBAS O. L., TERZİ Y. K., ÖZATİK O., ÖZATİK F. Y., Turna G., Nar R., ...More

JOURNAL OF PLASTIC SURGERY AND HAND SURGERY, vol.51, no.6, pp.405-413, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.1080/2000656x.2017.1285784
  • Journal Name: JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.405-413
  • Keywords: Notch, Dll4, TRAM, nicotine, survival, angiogenesis, DONOR-SITE COMPLICATIONS, PATTERN SKIN FLAPS, BREAST RECONSTRUCTION, TUMOR ANGIOGENESIS, CIGARETTE-SMOKING, GENE-THERAPY, BLOOD-FLOW, VIABILITY, MODEL, VEGF
  • Kütahya Health Sciences University Affiliated: No

Abstract

Background: Smoke of cigarettes, and specifically nicotine, has been shown to diminish pedicled transverse rectus abdominis musculocutaneous (TRAM) flap survival. Considering that Notch signalling through its ligand Delta-like 4 (Dll4) functions as anti-angiogenic factor by inhibiting the pro-angiogenic effects of vascular endothelial growth factor (VEGF), it is hypothesised that inhibition of the Notch would promote angiogenesis and increase TRAM flap survival in rats submitted to nicotine.