JOURNAL OF PLASTIC SURGERY AND HAND SURGERY, vol.51, no.6, pp.405-413, 2017 (Journal Indexed in SCI)
Article / Article
Title of Journal :
JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
Notch, Dll4, TRAM, nicotine, survival, angiogenesis, DONOR-SITE COMPLICATIONS, PATTERN SKIN FLAPS, BREAST RECONSTRUCTION, TUMOR ANGIOGENESIS, CIGARETTE-SMOKING, GENE-THERAPY, BLOOD-FLOW, VIABILITY, MODEL, VEGF
Background: Smoke of cigarettes, and specifically nicotine, has been shown to diminish pedicled transverse rectus abdominis musculocutaneous (TRAM) flap survival. Considering that Notch signalling through its ligand Delta-like 4 (Dll4) functions as anti-angiogenic factor by inhibiting the pro-angiogenic effects of vascular endothelial growth factor (VEGF), it is hypothesised that inhibition of the Notch would promote angiogenesis and increase TRAM flap survival in rats submitted to nicotine.