Enhancement of vascular endothelial growth factor's angiogenic capacity by the therapeutic modulation of notch signalling improves tram flap survival in rats submitted to nicotine


ABBAS O. L. , TERZİ Y. K. , ÖZATİK O. , ÖZATİK F. Y. , Turna G., Nar R., et al.

JOURNAL OF PLASTIC SURGERY AND HAND SURGERY, cilt.51, ss.405-413, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 51 Konu: 6
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/2000656x.2017.1285784
  • Dergi Adı: JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
  • Sayfa Sayısı: ss.405-413

Özet

Background: Smoke of cigarettes, and specifically nicotine, has been shown to diminish pedicled transverse rectus abdominis musculocutaneous (TRAM) flap survival. Considering that Notch signalling through its ligand Delta-like 4 (Dll4) functions as anti-angiogenic factor by inhibiting the pro-angiogenic effects of vascular endothelial growth factor (VEGF), it is hypothesised that inhibition of the Notch would promote angiogenesis and increase TRAM flap survival in rats submitted to nicotine.