Prognostic value of the monocyte/high density lipoprotein cholesterol ratio in diabetic nephropathy patients
Acta Medica Mediterranea, cilt.32, sa.4, ss.981-985, 2016 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 4
- Basım Tarihi: 2016
- Doi Numarası: 10.19193/0393-6384_2016_4_119
- Dergi Adı: Acta Medica Mediterranea
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.981-985
- Anahtar Kelimeler: Albuminuria, Diabetes mellitus, Diabetic nephropathy, High density lipoprotein, Monocyte
- Kütahya Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction: Diabetic nephropathy (DN), a microvascular complication associated with diabetes mellitus (DM), manifests in urinary albumin excretion (UAE) and may lead to end-stage renal failure. Recent studies have reported that the monocyte/high-density lipoprotein cholesterol ratio (MHR) serves as an inflammatory marker. The purpose of this study is to analyze the prognostic value of the MHR in DN patients. Material and methods: The medical records of type 2 DM patients who received follow-up care at the internal medicine clinic were examined, and the data of all patients who had undergone estimation of 24-hour UAE were recorded. These patients were separated into 3 groups on the basis of the UAE levels and the biochemical data and the MHR were compared between the groups. Results: The serum creatinine (p = 0.008), 24-hour UAE (p < 0.001), and MHR (p = 0.005) were all significantly different between the groups. The MHR was positively correlated to the 24-hour UAE (p = 0.007) and negatively correlated to the glomerular filtration rate (GFR) (p = 0.023). Conclusion: The MHR can be an inexpensive, accessible, and useful early prognostic marker in diabetic nephropathy patients.