Thrombolytic Therapy for the Treatment of Prosthetic Heart Valve Thrombosis in Pregnancy With Low-Dose, Slow Infusion of Tissue-Type Plasminogen Activator

ÖZKAN, MEHMET; ÇAKAL, BEYTULLAH; KARAKOYUN, SÜLEYMAN; GÜRSOY, OZAN; ÇEVİK, CİHAN; KALÇIK, MACİT; OĞUZ, ALİ; GÜNDÜZ, SABAHATTİN; ASTARCIOĞLU, MEHMET; AYKAN, AHMET; BAYRAM, ZÜBEYDE; BİTEKER, MURAT; KAYNAK, EVREN; KAHVECİ, GÖKHAN; Duran, Nilufer; YILDIZ, MUSTAFA

doi:10.1161/circulationaha.113.001145

Thrombolytic Therapy for the Treatment of Prosthetic Heart Valve Thrombosis in Pregnancy With Low-Dose, Slow Infusion of Tissue-Type Plasminogen Activator

ÖZKAN M., ÇAKAL B., KARAKOYUN S., GÜRSOY O. M., ÇEVİK C., KALÇIK M., ...Daha Fazla

CIRCULATION, cilt.128, sa.5, ss.532-542, 2013 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 128 Sayı: 5
Basım Tarihi: 2013
Doi Numarası: 10.1161/circulationaha.113.001145
Dergi Adı: CIRCULATION
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.532-542
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Kütahya Sağlık Bilimleri Üniversitesi Adresli: Hayır

Özet

Background-Prosthetic valve thrombosis during pregnancy is life-threatening for mother and fetus, and the treatment of this complication is unclear. Cardiac surgery in pregnancy is associated with very high maternal and fetal mortality and morbidity. Thrombolytic therapy has rarely been used in these patients. The aim of this study is to evaluate the safety and efficacy of low-dose (25 mg), slow infusion (6 hours) of tissue-type plasminogen activator for the treatment of prosthetic valve thrombosis in pregnant women.