Effects of Pseudevernia furfuracea (L.) Zopf on Helicobacter pylori induced gastritis in rats: anti- Helicobacter pylori and anti gastritis properties
Folia Microbiologica, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2026
- Doi Numarası: 10.1007/s12223-026-01428-y
- Dergi Adı: Folia Microbiologica
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core
- Anahtar Kelimeler: Antimicrobial, Helicobacter pylori, HIF-1α, IL-10, IL-1β, Pseudevernia furfuracea (L.) zopf
- Kütahya Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
We evaluated the antimicrobial and host-directed effects of Pseudevernia furfuracea (L.) Zopf (P. furfuracea) against Helicobacter pylori (H. pylori) associated gastritis. The acetone extract inhibited H. pylori growth in vitro, with a minimum inhibitory concentration (MIC) of 15.625 µg/mL, and modestly reduced pre-formed biofilms. In a rat model of indomethacin- and H. pylori induced gastritis, oral P. furfuracea treatment lowered gastric bacterial load and urease activity, shifted the cytokine profile toward an anti-inflammatory pattern (reduced interleukin-1β [IL-1β] and restored interleukin-10 [IL-10]), improved oxidative status (decreased malondialdehyde [MDA] and total oxidant status [TOS], increased reduced glutathione [GSH] and total antioxidant status [TAS]), and downregulated hypoxia-inducible factor-1α (HIF-1α) and transforming growth factor-β (TGF-β) transcripts. These molecular and biochemical changes were accompanied by better preservation of gastric mucosal architecture and reduced inflammatory cell infiltration. Overall, P. furfuracea exhibited a dual profile, combining direct anti H. pylori activity with mucosa-protective, host-directed effects. These findings support further development of standardized P. furfuracea preparations, including mechanistic, phytochemical, and dose–response studies, as potential adjuncts to conventional H. pylori therapies.