Synthesis and anticonvulsant activity of some ω-(1H-1-imidazolyl)-N- phenylalkanoic acid amide derivatives
Farmaco, vol.57, no.3, pp.201-206, 2002 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 57 Issue: 3
- Publication Date: 2002
- Doi Number: 10.1016/s0014-827x(01)01197-1
- Journal Name: Farmaco
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.201-206
- Keywords: Anilide, Anticonvulsant, Imidazole, MES
- Kütahya Health Sciences University Affiliated: Yes
Abstract
In this study, 15 ω-(1H-imidazol-1-yl)-N-phenylacetamide, propionamide and butyramide derivatives having methoxyl, methyl, nitro and chloro in ortho position of N-phenyl ring or without any substituent have been realized by two-step synthesis. Their anticonvulsant activity was determined against seizures induced by maximal electroshock (MES). The most active compound in the series was 2-(1H-imidazol-1-yl)-N-(o-chlorophenyl)acetamide. © 2002 Éditions scientifiques et médicales Elsevier SAS. All rights reserved.