New β-diketone and 3,5-dimethyl isoxazole derivatives of theophylline as potential bronchodilator agents
Arzneimittel-Forschung/Drug Research, cilt.48, sa.6, ss.658-662, 1998 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 48 Sayı: 6
- Basım Tarihi: 1998
- Dergi Adı: Arzneimittel-Forschung/Drug Research
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.658-662
- Anahtar Kelimeler: 2,4- Pentanediones, 3,5-Dimethylisoxazoles, Antiasthmatic drugs, Antihistaminic drugs, Theophylline, bronchodilator activity, Xanthine derivatives
- Kütahya Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Ten new compounds having 7-[(2,4-pentanedione-3-yl)alkyl]- and 7-[(3,5- dimethylisoxazole-4-yl)alkyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione structures were synthesized and their bronchodilator activities investigated using the method based on inhibition of acetylcholine and histamine-induced contractions in guinea pig trachea. None of the compounds were effective on acetylcholine-induced contractions. However, the compounds 4d, 4e, 5d and 5c were potent inhibitors of the bronchospasm induced by histamine, whereas the others (4b, 4c, 5b and 5c) were weak inhibitors.