Myo-inositol oxygenese activity in second trimester of pregnancy: altered myoinositol catabolism in gestational diabetes mellitus

Kisa B., Sert U. Y., Celik H. K., Candar T., Koc E. M. E., Tasci Y., ...More

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, vol.128, no.4, pp.910-913, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 128 Issue: 4
  • Publication Date: 2022
  • Doi Number: 10.1080/13813455.2020.1739714
  • Journal Name: ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.910-913
  • Keywords: gestational diabetes mellitus, second trimester, Serum Myo-inositol oxygenase
  • Kütahya Health Sciences University Affiliated: Yes

Abstract

Objective: We aimed to determine myo-inositol oxygenase (MIOX) activity in gestational diabetes mellitus (GDM). Material and Methods: The insulin, HbA1c, and MIOX levels of 80 pregnant women were analysed after 75 g OGTT. Group I included patients with no risk factor for GDM, Group II: patients with high risk for GDM, and Group III: GDM patients. Results: Fasting plasma glucose and Homeostatic Model Assessment for Insulin Resistance index were significantly higher in GDM cases (Group 3). Regarding the MIOX levels, significantly higher levels were recorded at 0-h in Group 3 compared to Groups 1 and 2. Significant alteration in MIOX activity was found between 0- and 2-h in Group 3 compared to Groups 1 and 2 (p < .029). Conclusions: MIOX levels were higher in GDM cases so, it may be have a role in myo-inositol catabolism.