Myo-inositol oxygenese activity in second trimester of pregnancy: altered myoinositol catabolism in gestational diabetes mellitus
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, vol.128, no.4, pp.910-913, 2022 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 128 Issue: 4
- Publication Date: 2022
- Doi Number: 10.1080/13813455.2020.1739714
- Journal Name: ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
- Page Numbers: pp.910-913
- Keywords: gestational diabetes mellitus, second trimester, Serum Myo-inositol oxygenase
- Kütahya Health Sciences University Affiliated: Yes
Abstract
Objective: We aimed to determine myo-inositol oxygenase (MIOX) activity in gestational diabetes mellitus (GDM). Material and Methods: The insulin, HbA1c, and MIOX levels of 80 pregnant women were analysed after 75 g OGTT. Group I included patients with no risk factor for GDM, Group II: patients with high risk for GDM, and Group III: GDM patients. Results: Fasting plasma glucose and Homeostatic Model Assessment for Insulin Resistance index were significantly higher in GDM cases (Group 3). Regarding the MIOX levels, significantly higher levels were recorded at 0-h in Group 3 compared to Groups 1 and 2. Significant alteration in MIOX activity was found between 0- and 2-h in Group 3 compared to Groups 1 and 2 (p < .029). Conclusions: MIOX levels were higher in GDM cases so, it may be have a role in myo-inositol catabolism.