Myo-inositol oxygenese activity in second trimester of pregnancy: altered myoinositol catabolism in gestational diabetes mellitus
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, cilt.128, sa.4, ss.910-913, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 128 Sayı: 4
- Basım Tarihi: 2022
- Doi Numarası: 10.1080/13813455.2020.1739714
- Dergi Adı: ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.910-913
- Anahtar Kelimeler: gestational diabetes mellitus, second trimester, Serum Myo-inositol oxygenase
- Kütahya Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: We aimed to determine myo-inositol oxygenase (MIOX) activity in gestational diabetes mellitus (GDM). Material and Methods: The insulin, HbA1c, and MIOX levels of 80 pregnant women were analysed after 75 g OGTT. Group I included patients with no risk factor for GDM, Group II: patients with high risk for GDM, and Group III: GDM patients. Results: Fasting plasma glucose and Homeostatic Model Assessment for Insulin Resistance index were significantly higher in GDM cases (Group 3). Regarding the MIOX levels, significantly higher levels were recorded at 0-h in Group 3 compared to Groups 1 and 2. Significant alteration in MIOX activity was found between 0- and 2-h in Group 3 compared to Groups 1 and 2 (p < .029). Conclusions: MIOX levels were higher in GDM cases so, it may be have a role in myo-inositol catabolism.