Vertebral fractures cause poor quality of life due to the back pain, functional limitations, and loss of utility. Therefore, the effects of vertebral fractures on quality of life is an important clinical issue. This study aimed to evaluate the prevalence and the effects of vertebral fractures on quality of life in seventy patients with osteoporosis. Bone mineral density were performed by dual-energy x-ray absorptiometry. Ouality of life was assessed by Short-Form 36 (SF-36). Spine radiographs were used to evaluate the existence of vertebral fracture. Primary and secondary osteoporosis were determined in 52.9 % and 47.1 % of the patients, respectively. Vertebral fractures were determined in 7 (18.9 %) patients with primary osteoporosis and in 6 (18.2 %) patients with secondary osteoporosis. When scores of SF-36 subgroups were compared, there was no statistically significant difference between the patients with and without vertebral fractures in primary osteoporosis. In conclusion, any meaningful relationship was found between vertebral fracture and quality of life in patients with primary osteoporosis with the instrument of SF-36.