TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.43, sa.5, ss.78-79, 2019 (SCI Expanded İndekslerine Giren Dergi)
OBJECTIVES:Diabetes mellitus is considered to be one of the five major causes
of death around the world and is considered a global public health problem due
to its multi-factorial characteristics affecting basic biochemical processes in
the body. Metformin (MET) is currently the most widely used first-line antihyperglycemic
agent for diabetes mellitus. Plants are important resource in the
discovery of anti-diabetic drugs. In order to explain the pharmacological basis
of the antidiabetic activity of Cistus laurifolius (CL), the effect on insulin,
lipase and amylase levels was examined in diabetic rats caused by STZ.
MATERIALS and METHODS:Fourty wistar male rats were divided into
5 groups, Group I Animals were served as control. Group II Animals were
injected intraperitoneally with a single dose of streptozotocin (STZ) (55mg/
kg of body weight (BW)) to induce diabetes. After 7 days, Group III and
V diabetic rats were treated with 250 mg/kg and 125 mg/kg of aqueous
extract of CL, respectively. Group IV diabetic rats were treated with 100
mg/kg MET in order to compare the effects of plant extracts. CL and MET
were orally administered to rats and after 4 hours blood samples were
taken. Blood levels of insulin, lipase and amylase were then measured.
RESULTS:A significant decrease (p<0.05) in the serum levels of insulin,
lipase and amylase were observed STZ-induced diabetic rats compare
with control groups. MET and aqueous extract of CL groups improved
levels of insulin, amylase and lipase compared with STZ group. Dosagedependent
effects of CL plant extracts did not change significantly (p>0.05).
CONCLUSIONS:These findings support the fact that
aqueous extract of Cistus laurifolius has an acute antidiabetic
effect and may be useful in controlling hyperglycemia.
Keywords: Diabetes Mellitus, Pancreatic functions, Metformin, Cistus laurifolius,
acute antidiabetic effect, hyperglicemia