CISTUS LAURIFOLIUS, AMELIORATES THE LEVELS OF INSULIN, AMYLASE AND LIPASE IN DIABETIC RATS


Kar F. , Hacıoğlu C., Kar E., Kara Y., Şentürk H., Yücel E., ...Daha Fazla

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.43, ss.78-79, 2019 (SCI Expanded İndekslerine Giren Dergi)

  • Cilt numarası: 43 Konu: 5
  • Basım Tarihi: 2019
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Sayfa Sayıları: ss.78-79

Özet

OBJECTIVES:Diabetes mellitus is considered to be one of the five major causes

of death around the world and is considered a global public health problem due

to its multi-factorial characteristics affecting basic biochemical processes in

the body. Metformin (MET) is currently the most widely used first-line antihyperglycemic

agent for diabetes mellitus. Plants are important resource in the

discovery of anti-diabetic drugs. In order to explain the pharmacological basis

of the antidiabetic activity of Cistus laurifolius (CL), the effect on insulin,

lipase and amylase levels was examined in diabetic rats caused by STZ.

MATERIALS and METHODS:Fourty wistar male rats were divided into

5 groups, Group I Animals were served as control. Group II Animals were

injected intraperitoneally with a single dose of streptozotocin (STZ) (55mg/

kg of body weight (BW)) to induce diabetes. After 7 days, Group III and

V diabetic rats were treated with 250 mg/kg and 125 mg/kg of aqueous

extract of CL, respectively. Group IV diabetic rats were treated with 100

mg/kg MET in order to compare the effects of plant extracts. CL and MET

were orally administered to rats and after 4 hours blood samples were

taken. Blood levels of insulin, lipase and amylase were then measured.

RESULTS:A significant decrease (p<0.05) in the serum levels of insulin,

lipase and amylase were observed STZ-induced diabetic rats compare

with control groups. MET and aqueous extract of CL groups improved

levels of insulin, amylase and lipase compared with STZ group. Dosagedependent

effects of CL plant extracts did not change significantly (p>0.05).

CONCLUSIONS:These findings support the fact that

aqueous extract of Cistus laurifolius has an acute antidiabetic

effect and may be useful in controlling hyperglycemia.

Keywords: Diabetes Mellitus, Pancreatic functions, Metformin, Cistus laurifolius,

acute antidiabetic effect, hyperglicemia