Antiadhesive and anti-inflammatory effects of pirfenidone in postoperative intra-abdominal adhesion in an experimental rat model

Bayhan, Zülfü; Zeren, SEZGİN; Koçak, FATMA; Koçak, CENGİZ; Akcılar, RAZİYE; Kargı, Ertuğrul; Tiryaki, Çağrı; Yaylak, FAİK; Akcılar, Aydın

doi:10.1016/j.jss.2015.11.033

Antiadhesive and anti-inflammatory effects of pirfenidone in postoperative intra-abdominal adhesion in an experimental rat model

Bayhan Z., Zeren S., Koçak F. E., Koçak C., Akcılar R., Kargı E., ...Daha Fazla

JOURNAL OF SURGICAL RESEARCH, cilt.201, sa.2, ss.348-355, 2016 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 201 Sayı: 2
Basım Tarihi: 2016
Doi Numarası: 10.1016/j.jss.2015.11.033
Dergi Adı: JOURNAL OF SURGICAL RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.348-355
Anahtar Kelimeler: Focal adhesions, Matrix metalloproteinases, Matrix metalloproteinase inhibitors, Peritoneal fibrosis, Pirfenidone, Postoperative complications, IDIOPATHIC PULMONARY-FIBROSIS, NECROSIS-FACTOR-ALPHA, GROWTH-FACTOR-BETA, PERITONEAL ADHESIONS, GENE-EXPRESSION, LIVER FIBROSIS, TNF-ALPHA, PREVENTION, PATHOPHYSIOLOGY, ANTAGONIST
Kütahya Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Background: Pirfenidone (PF) is a potent antifibrotic and anti-inflammatory agent. We investigated the protective effect of PF against postoperative intra-abdominal adhesions.