Antiadhesive and anti-inflammatory effects of pirfenidone in postoperative intra-abdominal adhesion in an experimental rat model

Bayhan, Zülfü; Zeren, SEZGİN; Koçak, FATMA; Koçak, Cengiz; Akcılar, RAZİYE; Kargı, Ertuğrul; Tiryaki, Çağrı; Yaylak, FAİK; Akcılar, Aydın

doi:10.1016/j.jss.2015.11.033

Antiadhesive and anti-inflammatory effects of pirfenidone in postoperative intra-abdominal adhesion in an experimental rat model

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Bayhan Z., Zeren S. , Koçak F. E. , Koçak C., Akcılar R. , Kargı E., ...More

JOURNAL OF SURGICAL RESEARCH, vol.201, no.2, pp.348-355, 2016 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 201 Issue: 2
Publication Date: 2016
Doi Number: 10.1016/j.jss.2015.11.033
Title of Journal : JOURNAL OF SURGICAL RESEARCH
Page Numbers: pp.348-355
Keywords: Focal adhesions, Matrix metalloproteinases, Matrix metalloproteinase inhibitors, Peritoneal fibrosis, Pirfenidone, Postoperative complications, IDIOPATHIC PULMONARY-FIBROSIS, NECROSIS-FACTOR-ALPHA, GROWTH-FACTOR-BETA, PERITONEAL ADHESIONS, GENE-EXPRESSION, LIVER FIBROSIS, TNF-ALPHA, PREVENTION, PATHOPHYSIOLOGY, ANTAGONIST

Abstract

Background: Pirfenidone (PF) is a potent antifibrotic and anti-inflammatory agent. We investigated the protective effect of PF against postoperative intra-abdominal adhesions.