The effect of nutrition and exercise training on irisin and semaphorin-3E levels in obese patients

Creative Commons License

Sezgin G., Kar F., Uslu S.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, vol.128, no.2, pp.558-567, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 128 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.1080/13813455.2020.1779310
  • Journal Name: ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.558-567
  • Keywords: Nutrition, insulin resistance, irisin, obesity, Sema3E, biomarker, C-REACTIVE PROTEIN, NECROSIS-FACTOR-ALPHA, BODY-MASS INDEX, WEIGHT-LOSS, CARBOHYDRATE INGESTION, INSULIN-RESISTANCE, CIRCULATING IRISIN, DIFFERENT BMI, RISK-FACTORS, INFLAMMATION
  • Kütahya Health Sciences University Affiliated: Yes

Abstract

We aimed to firstly examine the effects of nutrition and exercise training on irisin, Sema-3E, biochemical and inflammatory parameters in obese patients. This study was conducted using 37 individuals were divided into three groups according to body mass index (BMI) as non-obese, 1nd degree and 2nd degree obese individuals. Nutrition and exercise training were applied to groups for eight weeks. Insulin resistance decreased in non-obese and 1st degree obese subjects. HsCRP values decreased only in the second degree obese individuals. Adiponectin values were significantly decreased in all three groups. There was a negative correlation between serum adiponectin and plasma irisin levels both before and after treatment. Sema-3E levels increased significantly in only the first degree obese individuals, whereas plexin-D1 values did not change significantly in any group. Our findings indicate that nutrition and exercise training we apply improved both anthropometric measurements and biochemical parameters in obese and non-obese individuals.