Chitotriosidase as a novel biomarker of early atherosclerosis in hemodialysis patients

Creative Commons License

Güçlü A., Yılmaz M. İ., Tokmak T. T., Ünal H. U., Karaman M., Gezer M., ...Daha Fazla

HEMODIALYSIS INTERNATIONAL, cilt.21, sa.1, ss.41-46, 2017 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1111/hdi.12451
  • Dergi Adı: HEMODIALYSIS INTERNATIONAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.41-46
  • Anahtar Kelimeler: Chitotriosidase (CHIT-1), atherosclerosis, intima media thickness, hemodialysis, CORONARY-ARTERY-DISEASE, INTIMA-MEDIA THICKNESS, PLASMA CHITOTRIOSIDASE, CARDIOVASCULAR RISK, KIDNEY-DISEASE, MARKERS, PLAQUE, MACROPHAGES, MECHANISMS, CHITINASE
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Kütahya Sağlık Bilimleri Üniversitesi Adresli: Hayır

Özet

Introduction: Increasing evidence suggests that inflammation and increased macrophage activity have a central role in pathogenesis of atherosclerosis. It is shown that chitotriosidase (CHIT-1) is a marker of macrophage activity in atherosclerotic plaque, and is found associated with severity of atherosclerotic lesion. There is no data about CHIT-1 activity of hemodialysis patients in the literature. Thus, we hypothesized that in hemodialysis patients, CHIT-1 levels might be a novel biomarker in early atherosclerosis. Methods: Forty-five hemodialysis patients were included in the study (age: 61.93 +/- 613.34). Intima media thickness (IMT) was evaluated with high-resolution B-mode ultrasonography. Biomarker levels were measured in serum of patients. Findings: We found positive correlation among IMT, age (R: 0.426, P: 0.004) and, CHIT-1 value (R: 0.462, P: 0.001) in spearman correlation analysis. When age, CRP, creatinine, P, Alb, CHIT-1 were chosen as measures that can effect IMT in multiple regression model, IMT level was related with CHIT-1 (Beta: 0,396, P: 0.012) and age (Beta: 0,313 P: 0,048) independently. Discussion: In conclusion, this is the first report showing that serum CHIT-1 level was related independently with carotid IMT in hemodialysis patients. This biomarker might have an unknown role in the development of atherosclerosis during uremia.