The antimicrobial effect of r-limonene nanoemulsion on enterococcus faecalis
3rd International Gazi Pharma Symposium Series, Ankara, Türkiye, 8 - 10 Eylül 2021, ss.142, (Özet Bildiri)
- Yayın Türü: Bildiri / Özet Bildiri
- Basıldığı Şehir: Ankara
- Basıldığı Ülke: Türkiye
- Sayfa Sayıları: ss.142
- Kütahya Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
R-limonene is a terpene derivative, which has antimicrobial
activity [1]. The aim of this study is to evaluate the antibacterial efficacy
of R-limonene nanoemulsions against Enterococcus faecalis, which is
highly resistant to repetitive applications of calcium hydroxide used in the chemomechanical
preparation of root canal treatment [2]. Oil/water R-limonene nanoemulsions
were prepared by phase inversion method [3]. Formulation factors are listed in
the table below (Table 1). The particle size (PS), polydispersity index (PDI)
and zeta potential (ZP) values were evaluated and were given in the table below
(Table 2). It was observed that the ZP values decreased as the Tween 80 ratio
increased. Therefore, F3, F4 and F6 formulations were eliminated. F1, F2 and F5
formulations were subjected to a oneweek stability test at 4, 25 and 40 °C and
it was observed that the ZP of the F1 formulation decreased at all
temperatures. There were not significant changes in the F2 and F5 formulations.
The MIC values of F2 and F5 formulations were determined compared to pure
Rlimonene on Enterococcus faecalis. The MIC values of pure R limonene,
F2 and F5 were 210.3 mg/mL, 49.80 mg/mL and 48.82 mg/mL, respectively. These
results show that emulsion formulations of R-limonene are approximately 4.5
times more effective than pure R-limonene.