Adenomyosis and Uterine Fibr
DIAGNOSTICS, cilt.16, sa.18, ss.2968-2986, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 16 Sayı: 18
- Basım Tarihi: 2026
- Doi Numarası: 10.3390/diagnostics16182968
- Dergi Adı: DIAGNOSTICS
- Derginin Tarandığı İndeksler: Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Scopus, Science Citation Index Expanded (SCI-EXPANDED), EMBASE, Directory of Open Access Journals
- Sayfa Sayıları: ss.2968-2986
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Kütahya Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Adenomyosis and uterine fibroids are among the most common benign uterine disorders in
women of reproductive age and represent major causes of abnormal uterine bleeding, pelvic
pain, and infertility. Despite their distinct histopathological features, they frequently coexist
and share several hormonal and molecular mechanisms, making diagnosis and treatment
challenging. This narrative review examines the current evidence on their epidemiology,
pathophysiology, clinical presentation, imaging characteristics, reproductive impact, and
therapeutic management, with particular attention to the role of imaging in the differential
diagnosis and management of coexisting disease. A non-systematic narrative review of
the literature was conducted using PubMed/MEDLINE and Scopus. Relevant original
studies, systematic reviews, meta-analyses, consensus statements, and clinical guidelines
addressing adenomyosis, uterine fibroids, imaging, fertility, and treatment were considered.
Additional references were identified through manual screening of the bibliographies of
the retrieved articles. Although adenomyosis and uterine fibroids differ in their biological
origin and morphological appearance, they commonly present with overlapping symptoms,
including heavy menstrual bleeding, dysmenorrhea, chronic pelvic pain, and reproductive
dysfunction. Transvaginal ultrasound remains the first-line imaging modality, whereas
magnetic resonance imaging is particularly valuable in complex cases, lesion characteriza-
tion, and preoperative assessment. Accurate imaging phenotyping may help distinguish
isolated from coexisting disease and support individualized medical, surgical, or minimally
invasive treatment planning. A structured imaging-based approach integrated with clinical
findings and reproductive goals may improve disease characterization and support indi-
vidualized management of adenomyosis and uterine fibroids. Further standardization of imaging criteria and validation of emerging diagnostic technologies may improve patient
stratification and treatment selection.