Research Information System
EXPERIMENTAL AND THERAPEUTIC MEDICINE, vol.28, no.414, pp.1-8, 2024 (SCI-Expanded)
Abstract. The present retrospective cross‑sectional study
aimed to evaluate the predictive value of blood parameters
and ratios for predicting mortality in patients with hip frac‑
tures. In total, 758 patients with hip fractures attending the
Department of Orthopedics and Traumatology, Kütahya
Health Sciences University Faculty of Medicine (Kütahya,
Turkey) between January 2016 and January 2023 were
included in the present study. Patients were then divided
into two groups, namely the mortality (n=464; 61.2%) and
survivor (n=294; 38.8%) groups. Patients in the mortality
group were further sub‑divided into the following three
subgroups: i) Those who succumbed in <1 month (n=117;
25.2%); ii) those who succumbed between 1 and 12 months
(n=185; 39.9%); and iii) those who succumbed >12 months
later (n=162; 34.9%). In addition, the RDW coefficient of
variation, mean platelet volume (MPV), MPV/platelet ratio,
neutrophil‑to‑lymphocyte ratio, monocyte‑to‑lymphocyte
ratio, platelet‑to‑lymphocyte ratio (PLR), mean platelet
volume‑to‑lymphocyte ratio and monocyte‑to‑eosinophil
ratio means were all found to be significantly higher in the
mortality group (P<0.05). MPV (P<0.01), HGB (P<0.05),
eosinophil, EOS (P<0.01), HRR (P<0.01), and PLR (P<0.05)
were all revealed to exert significant effects on mortality.
An age cut‑off of 74.50 years had a sensitivity of 81.5%
and specificity of 37.1%, whereas an MPV cut‑off of 8.85
yielded a sensitivity of 73.5% and specificity of 36.1%. By
contrast, an HGB cutoff of 11.05 had a sensitivity of 55.6%
and specificity of 35.7%, an eosinophil cut‑off of 0.065
had a sensitivity of 47.6% and specificity of 35.4%, whilst
a HRR cut‑off of 0.7587 had a sensitivity of 55.2% and
specificity of 30.3%. Furthermore, a PLR cut‑off of 152.620
had a sensitivity of 67.2% and specificity of 41.8% for hip
fracture‑associated mortality. An age cut‑off of 79.50 years
had a sensitivity of 70.9% and specificity of 41.5%, while
an age cut‑off of 83.50 years had a sensitivity of 46.2% and
specificity of 64.0% for mortality occurring <1 month after
hip fractures. To conclude, results from the present study
suggested that HRR has potential predictive value for hip
fracture‑associated mortality and 30‑day mortality, whereas
the PLR could only predict hip fracture‑associated mortality.