Synthesis and biological activities of some thiazolidin-4-ones
Arzneimittel-Forschung/Drug Research, cilt.56, sa.10, ss.678-681, 2006 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 56 Sayı: 10
- Basım Tarihi: 2006
- Doi Numarası: 10.1055/s-0031-1296772
- Dergi Adı: Arzneimittel-Forschung/Drug Research
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.678-681
- Anahtar Kelimeler: Antihistaminic agents, Thiazolidin-4-ones, anti-cholinergic activity, anti-histaminic activity, synthesis
- Kütahya Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
In this study, fifteen 2,3-disubstituted-4-thiazolidinone derivatives were synthesized by the reaction of Schiff bases and α-mercaptoacetic acid. The structures of the compounds were elucidated by IR, 1H-NMR, 13C-NMR, mass spectral data and elementary analysis. The antihistaminic and anticholinergic activities of the compounds were determined by tests performed on isolated guinea pig trachea in comparison with aminophylline (CAS 317-34-0). Compound 15 (3-(3-(2-methyl-piperidine-1-yl) propyl]-2-(4-methylphenyl) thiazolidin-4-one hydrochloride) showed the highest inhibition (53%). © ECV · Editio Cantor Verlag.