Synthesis and anticonvulsant activity of some (2/4- substituted)benzaldehyde (2-oxobenzothiazolin-3-yl)acetohydrazones

Çakir, Bilge; YILDIRIM, ENGİN; Ercanli, Taner; EROL, KEVSER; ŞAHİN, MELEK

doi:10.1016/s0014-827x(99)00110-x

Synthesis and anticonvulsant activity of some (2/4- substituted)benzaldehyde (2-oxobenzothiazolin-3-yl)acetohydrazones

Çakir B., YILDIRIM E., Ercanli T., EROL K., ŞAHİN M. G.

Farmaco, vol.54, no.11-12, pp.842-845, 1999 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 54 Issue: 11-12
Publication Date: 1999
Doi Number: 10.1016/s0014-827x(99)00110-x
Journal Name: Farmaco
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.842-845
Keywords: Acetohydrazones, Anticonvulsant activity, Pentylenetetrazole
Kütahya Health Sciences University Affiliated: Yes

Abstract

Fifteen new (2/4-substituted)benzaldehyde (2-oxobenzothiazolin-3- yl)acetohydrazones were synthesized and their structures were elucidated by NMR and elemental analysis. Their anticonvulsant activity was tested by a pentylenetetrazole induced seizure test. Compounds 4e and 4h were found to be the most promising among the others.