Research Information System
IRANIAN RED CRESCENT MEDICAL JOURNAL, vol.1, no.1, pp.1-7, 2024 (SCI-Expanded)
Abstract
Background and Objectives: Vitamin B12 (cobalamin) is a vitamin that has important functions in our body. It plays a role in many systems, especially the nervous system. This study was conducted to evaluate the effects of vitamin B12 supplementation on sleep and quality of life in individuals with low blood cobalamin levels.
Methods: The Pittsburgh sleep quality index (PSQI) and short form of the quality-of-life (SF-36) scale were administered to 238 patients with blood B12 levels of <200 ng/L before and 2 months after B12 treatment.
Results: The mean sleep duration of the participants was 6.46 ± 1.87 h at pre-treatment and 7.44 ± 1.42 h post-treatment, and the mean PSQI decreased from 9.77 ± 5.01 to 4.31 ± 3.59, indicating an increase in sleep quality, which was statistically significant (P = 0.02, P < 0.05). It was observed that sleep duration increased and the time to fall asleep shortened. It was observed that the mean scores of sub-dimensions of the SF36 scale increased positively with the B12 treatment (P < 0.05).
Conclusion: In this study, cyanocobalamin treatment was positively affected by sleep quality and quality of life in individuals with cobalamin deficiency (P < 0.001). Positive increases were also observed in the SF36 quality-of-life scale (P < 0.05).