Silymarin attenuates the renal ischemia/reperfusion injury-induced morphological changes in the rat kidney


ŞENTÜRK H., KABAY Ş. , BAYRAMOĞLU G., ÖZDEN H., YAYLAK F., YÜCEL M., et al.

WORLD JOURNAL OF UROLOGY, cilt.26, ss.401-407, 2008 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 26 Konu: 4
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1007/s00345-008-0256-1
  • Dergi Adı: WORLD JOURNAL OF UROLOGY
  • Sayfa Sayısı: ss.401-407

Özet

Objectives Renal ischemia/reperfusion (I/R) injury is associated with increased mortality and morbidity rates due to acute renal failure (ARF). Oxidative stress induced with renal I/R injury directly affects glomerular and tubular epithelium through reactive oxygen species. Several studies have been directed to the treatment of renal I/R injury. The aim of this study was to test the attenuation with silymarin (SM) treatment of renal I/R injury-induced morphological changes in the rat kidney.