Studies on some 10-[2-(N,N-disubstituted thiocarbamoylthio)acetyl]phenothiazine derivatives
Arzneimittel-Forschung/Drug Research, cilt.42, sa.12, ss.1453-1455, 1992 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 42 Sayı: 12
- Basım Tarihi: 1992
- Dergi Adı: Arzneimittel-Forschung/Drug Research
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.1453-1455
- Anahtar Kelimeler: anticholinergic drugs, dithiocarbamates, pharmacology, synthesis, spasmolytics
- Kütahya Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Nineteen 10-[2-(N,N-disubstituted thiocarbamolythio)acetyl]phenothiazine derivatives have been synthesized by the reaction of 10-chloroacetylphenothiazine with potassium salt of N,N-disubstituted dithiocarbamic acid derivatives. The structures of the compounds have been elucidated by UV, IR, 1H-NMR spectra and microanalysis. The anticholinergic activity of the compounds was determined by assessing the inhibition of acetylcholine using atropine sulfate as a control. Results are discussed in relation to the activity and structure of the synthesized compounds.