Comparison of the Effects of Lamotrigine and Valproate on the Pentylenetetrazole-Induced Seizures and Behaviour of Immature Rats

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Göl M. F., ERDOĞAN F. F., KÜÇÜK A., GÖLGELİ A.

EPILEPSI, vol.24, no.3, pp.120-126, 2018 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.14744/epilepsi.2018.55477
  • Journal Name: EPILEPSI
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.120-126
  • Kütahya Health Sciences University Affiliated: Yes

Abstract

Objectives: Epileptics, especially children, are more prone to behavioural deficits. Epilepsy related factors, psychosocial problems, treatment side effects may aggravate such deficits. We investigated the effects of lamotrigine and valproate on the behaviour, and pentylenetetrazol (PTZ)-induced seizures on immature rats (21-day-old male).