MicroRNA-125b as a new potential biomarker on diagnosis of renal ischemia-reperfusion injury


Güçlü A., Koçak C., Koçak F. E. , Akcılar R. , Dodurga Y., Akcılar A., et al.

JOURNAL OF SURGICAL RESEARCH, cilt.207, ss.241-248, 2017 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 207
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.jss.2016.08.067
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Sayfa Sayısı: ss.241-248

Özet

Background: Acute renal failure is commonly seen in the perioperative period. Ischemia-reperfusion (IR) injury plays a major role in acute renal failure and delayed graft function. MicroRNAs (miRs), which are pivotal modulators of cell activities, offer a major opportunity for affective diagnosis and treatment strategies because they are tissue specific and in the center of gene expression modulation. The effect of bardoxolone methyl (BM) on miR-21, miR-223-5p, and miR-125b in renal IR injury was evaluated in this study.