MicroRNA-125b as a new potential biomarker on diagnosis of renal ischemia-reperfusion injury

Güçlü A., Koçak C., Koçak F. E., Akcılar R., Dodurga Y., Akcılar A., ...Daha Fazla

JOURNAL OF SURGICAL RESEARCH, cilt.207, ss.241-248, 2017 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 207
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.jss.2016.08.067
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.241-248
  • Anahtar Kelimeler: Renal ischemia-reperfusion injury, Bardoxolone methyl, CDDO-Me, MicroRNAs, miR-223-5p, miR-21, miR-125b, NF-KAPPA-B, OXIDATIVE STRESS, ISCHEMIA/REPERFUSION INJURY, BARDOXOLONE METHYL, CELL CARCINOMA, UP-REGULATION, KIDNEY, CANCER, APOPTOSIS, ACTIVATION
  • Kütahya Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Background: Acute renal failure is commonly seen in the perioperative period. Ischemia-reperfusion (IR) injury plays a major role in acute renal failure and delayed graft function. MicroRNAs (miRs), which are pivotal modulators of cell activities, offer a major opportunity for affective diagnosis and treatment strategies because they are tissue specific and in the center of gene expression modulation. The effect of bardoxolone methyl (BM) on miR-21, miR-223-5p, and miR-125b in renal IR injury was evaluated in this study.