MicroRNA-125b as a new potential biomarker on diagnosis of renal ischemia-reperfusion injury

Güçlü A., Koçak C., Koçak F. E., Akcılar R., Dodurga Y., Akcılar A., ...More

JOURNAL OF SURGICAL RESEARCH, vol.207, pp.241-248, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 207
  • Publication Date: 2017
  • Doi Number: 10.1016/j.jss.2016.08.067
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.241-248
  • Keywords: Renal ischemia-reperfusion injury, Bardoxolone methyl, CDDO-Me, MicroRNAs, miR-223-5p, miR-21, miR-125b, NF-KAPPA-B, OXIDATIVE STRESS, ISCHEMIA/REPERFUSION INJURY, BARDOXOLONE METHYL, CELL CARCINOMA, UP-REGULATION, KIDNEY, CANCER, APOPTOSIS, ACTIVATION
  • Kütahya Health Sciences University Affiliated: Yes

Abstract

Background: Acute renal failure is commonly seen in the perioperative period. Ischemia-reperfusion (IR) injury plays a major role in acute renal failure and delayed graft function. MicroRNAs (miRs), which are pivotal modulators of cell activities, offer a major opportunity for affective diagnosis and treatment strategies because they are tissue specific and in the center of gene expression modulation. The effect of bardoxolone methyl (BM) on miR-21, miR-223-5p, and miR-125b in renal IR injury was evaluated in this study.