© 2016 IEEE.Sensing and measurement methods with Quartz Crystal Microbalance (QCM) based sensors draw attention as an improving application among studies in recent years. This study is carried out for to be basis of studies on glucose level measurement using human blood serum using QCM sensors. In this paper, measurements with QCM sensor system using pure water containing several levels of glucose samples are carried out. Measurement results are analyzed with plots. The obtained results show that QCM based sensors are sensitive, repeatable and reliable sensor applications for blood glucose measurements.