Effect of picroside II on hind limb ischemia reperfusion injury in rats


KILIÇ Y., ÖZER A., TATAR T., ZOR M. H. , KİRİŞÇİ M., KARTAL H., ...More

DRUG DESIGN DEVELOPMENT AND THERAPY, vol.11, pp.1917-1925, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11
  • Publication Date: 2017
  • Doi Number: 10.2147/dddt.s132401
  • Title of Journal : DRUG DESIGN DEVELOPMENT AND THERAPY
  • Page Numbers: pp.1917-1925
  • Keywords: ischemia reperfusion, picroside II, hind limb skeletal muscle, TOS, TAS, TOTAL ANTIOXIDANT CAPACITY, SKELETAL-MUSCLE, MYOCARDIAL-ISCHEMIA, PICRORHIZA-KURROA, RENAL INJURY, VITAMIN-C, MODEL, LUNG, ILOPROST

Abstract

Introduction: Many structural and functional damages are observed in cells and tissues after reperfusion of previously viable ischemic tissues. Acute ischemia reperfusion (I/R) injury of lower extremities occurs especially when a temporary cross-clamp is applied to the abdominal aorta during aortic surgery. Research regarding the treatment of I/R injury has been increasing day-by-day. In this study, we aimed to investigate the effect of picroside II on skeletal muscle of rats experiencing simulated I/R.