Effect of picroside II on hind limb ischemia reperfusion injury in rats


KILIÇ Y., ÖZER A., TATAR T., ZOR M. H. , KİRİŞÇİ M., KARTAL H., et al.

DRUG DESIGN DEVELOPMENT AND THERAPY, cilt.11, ss.1917-1925, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 11
  • Basım Tarihi: 2017
  • Doi Numarası: 10.2147/dddt.s132401
  • Dergi Adı: DRUG DESIGN DEVELOPMENT AND THERAPY
  • Sayfa Sayısı: ss.1917-1925

Özet

Introduction: Many structural and functional damages are observed in cells and tissues after reperfusion of previously viable ischemic tissues. Acute ischemia reperfusion (I/R) injury of lower extremities occurs especially when a temporary cross-clamp is applied to the abdominal aorta during aortic surgery. Research regarding the treatment of I/R injury has been increasing day-by-day. In this study, we aimed to investigate the effect of picroside II on skeletal muscle of rats experiencing simulated I/R.