Curcumin and LOXblock-1 ameliorate ischemia-reperfusion induced inflammation and acute kidney injury by suppressing the semaphorin-plexin pathway


Kar F. , Hacioglu C., Şentürk H., Donmez D. B. , Kanbak G., Uslu S.

LIFE SCIENCES, vol.256, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 256
  • Publication Date: 2020
  • Doi Number: 10.1016/j.lfs.2020.118016
  • Title of Journal : LIFE SCIENCES
  • Keywords: AKI, Renal I/R, SEMA3A, Curcumin, LOXblock-1, RENAL ISCHEMIAREPERFUSION INJURY, ISCHEMIA/REPERFUSION INJURY, LIVER, ASSAY

Abstract

Aims: Ischemia/reperfusion (I/R) is one of the most important causes of acute kidney injury (AKI), a clinical syndrome with kidney dysfunction and high mortality rates. New diagnostic biomarkers need to be defined to better illuminate the pathophysiology of AKI. For the first time, we aim to investigate the protective effects of Curcumin which is known for its antioxidant and anti-inflammatory properties and 12/15 lipoxygenase inhibitor LOXblock-1 on I/R induced AKI by modulating inflammatory processes, oxidative stress, apoptosis and semaphorin-plexin pathway.