Protective and antigenotoxic effects of silymarin and curcumin in experimental cyclophosphamide intoxication in rats Ratlarda deneysel siklofosfamid toksikasyonunda silimarin ve curcuminin koruyucu ve antigenotoksik etkileri

Avci H., Sekkın S., Boyacioğlu M., Akşıt H., Tunca R., Epıkmen E. T., ...More

Kafkas Universitesi Veteriner Fakultesi Dergisi, vol.22, no.5, pp.693-701, 2016 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.9775/kvfd.2016.15145
  • Journal Name: Kafkas Universitesi Veteriner Fakultesi Dergisi
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.693-701
  • Keywords: Biochemistry, Comet assay, Curcumin, Cyclophosphamide, Pathology, Silymarin
  • Kütahya Health Sciences University Affiliated: No

Abstract

The aim of this study was to investigate the protective effects of silymarin (SLY) and curcumin (CUR), which have strong antioxidant properties, against the toxic effects of high dose of cyclophosphamide (CP) on the liver and kidneys of rats. For this purpose, a total of 36 adult Wistar albino female rats at the weight of, 250±10 g were used. Biochemical parameters were found to be significantly higher in the CP-only group than in the other groups. In the groups in which SLY and CUR were administered concurrently with CP, biochemical parameters were found to be significantly lower than in the CP-only group. In the SLY+CP and CUR+CP groups, biochemical parameters were correlated with the severity of histopathological findings. In genotoxic examination, the comet parameter levels in the SLY+CP and CUR+CP-treated groups were lower than those in the CP-treated group. The present study established that both SLY and CUR are effective against the toxic effects of high doses of CP.