Synthesis of some triazolyl-antipyrine derivatives and investigation of analgesic activity
European Journal of Medicinal Chemistry, vol.36, no.7-8, pp.685-689, 2001 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 36 Issue: 7-8
- Publication Date: 2001
- Doi Number: 10.1016/s0223-5234(01)01252-1
- Journal Name: European Journal of Medicinal Chemistry
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.685-689
- Keywords: Analgesic activity, Antipyrine, Triazoles
- Kütahya Health Sciences University Affiliated: Yes
Abstract
The synthesis of some triazolyl-antipyrine derivatives starting from 4-chloroacetamidoantipyrine and 3-(aryloxyalkyl)-4-ethyl/phenyl-5-mercapto-1,2,4-triazoles is described. The chemical structures of the compounds were elucidated by IR, 1H-NMR and mass spectral studies. These compounds were tested for analgesic activity. © 2001 Éditions scientifiques et médicales Elsevier SAS.