Background and aims: Obesity is a common disorder and is a known risk factor for vascular thrombotic events. The protein C anticoagulant system serves many anti-inflammatory functions. The soluble form of endothelial protein C (sEPCR) circulating in plasma precludes protein C activation and inhibits the anticoagulant activity of activated protein C. The aim of the study is to determine high sensitive C-reactive protein (CRP) and soluble EPCR levels among obese women. Methods: Seventy five postmenopausal women were enrolled in to one of two groups according to body mass index (BMI), 45 obese (BMI >= 30 kg/m(2)) and 30 non-obese (BMI<30 kg/m(2)). Plasma levels of soluble EPCR and hsCRP were determined by ELISA. Results: HsCRP was significantly higher in the obese subjects compared to their non-obese counterparts (0.90 +/- 1.25 mg/l vs 0.46 +/- 0.45 mg/l, p=0.006). Soluble EPCR levels did not differ between the obese and non-obese groups (p=0.494). HsCRP was positively correlated with BMI and waist circumference (r=0.341, p=0.004; r=0.348, p=0.04, respectively). Soluble EPCR showed no significant correlation with these measures. Conclusions: We also detected a wide range of interindividual variability in sEPCR level (40.77-892.82 ng/ml for non obese, 6.09-1339.25 ng/ml for obese). Although the obese had higher sEPCR, the difference was not statistically significant. A well-established inflammatory marker, hsCRP was significantly higher in the obese. There was no relation between hsCRP and sEPCR. Consequently we suggest that sEPCR does not contribute to the inflammation and increased propensity for coagulation in the postmenopausal stage. Obesity and Metabolism 2009; 5: 134-138.