Is there a genetic predisposition for Turkish patients with sarcoidosis in the 329-bp region containing the BTNL2 rs2076530 polymorphism?

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Ozdemir M., Saydam F., Kurt E., Degirmenci I., Tuncel T., Cilingir O., ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.44, no.4, pp.590-594, 2014 (SCI-Expanded, Scopus, TRDizin)

• Publication Type: Article / Article
• Volume: 44 Issue: 4
• Publication Date: 2014
• Doi Number: 10.3906/sag-1306-16
• Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.590-594
• Open Archive Collection: AVESIS Open Access Collection
• Kütahya Health Sciences University Affiliated: No

Abstract

Background/aim: Sarcoidosis is a complex, multifactorial immune disorder with unknown etiology. A single nucleotide polymorphism (G -> A, rs2076530) in the butyrophilin-like 2 (BTNL2) gene results in a truncating protein formation. It has been previously reported that this variation may be a risk factor for sarcoidosis in certain ethnic groups. This study was conducted to determine whether there is any genetic predisposition for the BTNL2 rs2076530 polymorphism in the 329-bp region in Turkish patients with sarcoidosis.