Prolidase activity and oxidative stress in patients with breast carcinoma A prospective randomized case-controlled study


Bayhan Z., Zeren S. , Koçak C., Koçak F. E. , Düzgün Ş. A. , Algın M. C. , ...More

ANNALI ITALIANI DI CHIRURGIA, vol.87, no.6, pp.517-524, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 87 Issue: 6
  • Publication Date: 2016
  • Title of Journal : ANNALI ITALIANI DI CHIRURGIA
  • Page Numbers: pp.517-524
  • Keywords: Breast carcinoma, Oxidative stress, Proline dipeptidase, SERUM PROLIDASE, FREE-RADICALS, UPDATE

Abstract

INTRODUCTION: Oxidative stress plays an important role in the pathogenesis of malign diseases. Prolidase is a member of the matrix metalloproteinase family, plays a major role in collagen metabolism, cell growth, and matrix remodeling. Elevated serum prolidase activity have beendemonstrated in several types of carcinoma. The aim of this study is to investigate the serum prolidase activity, total oxidant status (TOS), total antioxidant status (TAS) and to evaluate their relationship with tumor stage, lymph node metastasis, and tumor size in patients with breast carcinoma.