Effects of ciprofloxacin on chromosomes, and hepatic and renal functions in rats
Chemotherapy, cilt.39, sa.3, ss.182-188, 1993 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 39 Sayı: 3
- Basım Tarihi: 1993
- Doi Numarası: 10.1159/000239124
- Dergi Adı: Chemotherapy
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.182-188
- Anahtar Kelimeler: Chromatid-type breakage, Ciprofloxacin, Creatinine clearance
- Kütahya Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
In the present study, ciprofloxacin, a fluoroquinolone antibiotic, was evaluated in vivo. The toxic effects of ciprofloxacin (20 and 200 mg/kg/day) on kidney and liver functions, and on chromosomes were investigated in rats. 20 mg/kg/day ciprofloxacin did not significantly affect urine composition, serum enzyme levels and the haematocrit, affecting only creatinine clearance. The 200 mg/kg/day dose increased urine volume, serum creatinine and and creatinine clearance. Ciprofloxacin at both doses had no significant numerical effect on chromosomes, but there was a statistically significant dose-dependent increase in chromatid-type breakage. Significant histological changes in the liver and kidney were not observed. © 1993 S. Karger AG, Basel.