Effect of IL-18 binding protein on hepatic ischemia-reperfusion injury induced by infrarenal aortic occlusion

ÖZSOY, MUSTAFA; GÖNÜL, YÜCEL; Bal, Ahmet; Ozkececi, Ziya; Celep, Ruchan; Adali, Fahri; Hazman, Omer; Kocak, AHMET; Tosun, Murat

doi:10.4174/astr.2015.88.2.92

Effect of IL-18 binding protein on hepatic ischemia-reperfusion injury induced by infrarenal aortic occlusion

ÖZSOY M., GÖNÜL Y., Bal A., Ozkececi Z. T. , Celep R. B. , Adali F., ...More

ANNALS OF SURGICAL TREATMENT AND RESEARCH, vol.88, no.2, pp.92-99, 2015 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 88 Issue: 2
Publication Date: 2015
Doi Number: 10.4174/astr.2015.88.2.92
Title of Journal : ANNALS OF SURGICAL TREATMENT AND RESEARCH
Page Numbers: pp.92-99

Abstract

Purpose: Severe Local and systemic tissue damage called ischemia/reperfusion (IR) injury occurs during the period of reperfusion. Free oxygen radicals and proinflammatory cytokines are responsible for reperfusion injury. IL-18 binding protein (IL-18BP) is a natural inhibitor of IL-18. The balance between IL-18 and IL-18BP has an important role in the inflammatory setting. The present study aimed to investigate whether IL-18BP had a protective role in remote organ hepatic IR injury.