Effect of IL-18 binding protein on hepatic ischemia-reperfusion injury induced by infrarenal aortic occlusion


Creative Commons License

ÖZSOY M., GÖNÜL Y., Bal A., Ozkececi Z. T., Celep R. B., Adali F., ...More

ANNALS OF SURGICAL TREATMENT AND RESEARCH, vol.88, no.2, pp.92-99, 2015 (SCI-Expanded) identifier identifier identifier

Abstract

Purpose: Severe Local and systemic tissue damage called ischemia/reperfusion (IR) injury occurs during the period of reperfusion. Free oxygen radicals and proinflammatory cytokines are responsible for reperfusion injury. IL-18 binding protein (IL-18BP) is a natural inhibitor of IL-18. The balance between IL-18 and IL-18BP has an important role in the inflammatory setting. The present study aimed to investigate whether IL-18BP had a protective role in remote organ hepatic IR injury.