Effect of IL-18 binding protein on hepatic ischemia-reperfusion injury induced by infrarenal aortic occlusion

ÖZSOY, MUSTAFA; GÖNÜL, YÜCEL; Bal, Ahmet; Ozkececi, Ziya; Celep, Ruchan; Adali, Fahri; Hazman, Omer; Kocak, AHMET; Tosun, Murat

doi:10.4174/astr.2015.88.2.92

Effect of IL-18 binding protein on hepatic ischemia-reperfusion injury induced by infrarenal aortic occlusion

ÖZSOY M., GÖNÜL Y., Bal A., Ozkececi Z. T., Celep R. B., Adali F., ...Daha Fazla

ANNALS OF SURGICAL TREATMENT AND RESEARCH, cilt.88, sa.2, ss.92-99, 2015 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 88 Sayı: 2
Basım Tarihi: 2015
Doi Numarası: 10.4174/astr.2015.88.2.92
Dergi Adı: ANNALS OF SURGICAL TREATMENT AND RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.92-99
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Kütahya Sağlık Bilimleri Üniversitesi Adresli: Hayır

Özet

Purpose: Severe Local and systemic tissue damage called ischemia/reperfusion (IR) injury occurs during the period of reperfusion. Free oxygen radicals and proinflammatory cytokines are responsible for reperfusion injury. IL-18 binding protein (IL-18BP) is a natural inhibitor of IL-18. The balance between IL-18 and IL-18BP has an important role in the inflammatory setting. The present study aimed to investigate whether IL-18BP had a protective role in remote organ hepatic IR injury.