Obezite ACSL4 ve GPX4 Aracılı Ferroptozis ile Oksidatif Stresi İndükler


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Sezgin G., Kar F. , Hacıoğlu C., Uslu S.

Osmangazi Tıp Dergisi, vol.44, no.2, pp.224-230, 2022 (Other Refereed National Journals)

  • Publication Type: Article / Article
  • Volume: 44 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.20515/otd.986897
  • Title of Journal : Osmangazi Tıp Dergisi
  • Page Numbers: pp.224-230

Abstract

In this study, the parameters of oxidative stress markers and ferroptosis were evaluated in experimental groups of adult individuals, which were formed according to the body mass index (BMI). A total of 39 adult patients were normal weight or overweight (BMI: 18.5-29.9), first degree obese (BMI 30-34.9) and second degree obese (BMI: 35-39.9) were divided into three groups of thirteen each.. From the serum samples of healthy individuals in the control group and patients in the obesity groups, malondialdehyde (MDA), total antioxidant capacity (TAS), total oxidant capacity (TOS), glutathione (GSH), Acyl-CoA synthetase long chain family member 4 (ACSL4) and glutathione peroxidase 4 (GPx4) levels were measured. Compared to the control group, TOS levels increased in grade 1 and grade 2 obese patients (p<0.0001), while TAS levels decreased in grade 1 obese and grade 2 obese patients (p<0.001). MDA levels were increased in grade 1 obese (p<0.001) and grade 2 obese patients (p<0.0001) compared to the control group. GSH levels decreased as the degree of obesity increased (p<0.001). Compared to the control group, ACSL4 levels of 1st and 2nd obese patients increased (p<0.001), while GPx4 levels decreased in both obese groups (p<0.001). As the degree of obesity increases, lipid peroxidation and oxidative stress increase. In addition, when the decrease in GPx4 levels and the increase in ACSL4 levels in obese individuals compared to the control group are evaluated together, it can be thought that obesity induces ferroptosis.