Memory Function and Total Pyramidal Neuron Number of Hippocampus in Streptozotocin-induced Diabetic Rats

YONGUÇ G. N., ÖZDEMİR M. B., KÜÇÜKATAY V., ŞAHİNER A. M., AKCILAR R., ADIGÜZEL E., ...More

JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, vol.31, no.3, pp.461-473, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 3
  • Publication Date: 2014
  • Journal Name: JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.461-473
  • Keywords: Hippocampus, Diabetes, Memory impairment, Stereology, Optical fractionator method, Morris Water Maze, SYNAPTIC PLASTICITY, DEMENTIA, PERFORMANCE, IMPAIRMENT, MELLITUS, INSULIN, STRESS, RISK
  • Kütahya Health Sciences University Affiliated: No

Abstract

Introduction: Cognitive impairments caused by diabetes mellitus are well documented by previous studies. The studies about neuronal deficits and cognitive impairments in animal models of diabetes mellitus do not simultaneously indicate the total neuron number in the brain subfields and cognitive test performance. In this study, we simultaneously demonstrated total pyramidal neuron number of hippocampus and water maze test performance in streptozotocin-induced diabetic rats.