Comparison of the bioavailability of oral and rectal forms of diphenylhydantoin sodium
Drug Development and Industrial Pharmacy, cilt.16, sa.11, ss.1849-1856, 1990 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 16 Sayı: 11
- Basım Tarihi: 1990
- Doi Numarası: 10.3109/03639049009025792
- Dergi Adı: Drug Development and Industrial Pharmacy
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.1849-1856
- Kütahya Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
The bioavailabilities of single 100-mg oral and rectal doses of diphenylhydantoin sodium were studied in five healthy volunteers. The rectal form used was prepared at laboratory conditions and the oral form was a commercial preparation. Blood samples were analysed over a 72-hr period. Evaluation of the AUC, tmax and Cmax values have shown that the total absorption after the two routes of administration was the same while the Cmax and tmax differed. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.