Interleukin-1α, interleukin-1β, and interleukin-1Ra polymorphisms in febrile seizures
Journal of Child Neurology, cilt.20, sa.7, ss.565-568, 2005 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 20 Sayı: 7
- Basım Tarihi: 2005
- Doi Numarası: 10.1177/08830738050200070401
- Dergi Adı: Journal of Child Neurology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.565-568
- Kütahya Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Febrile seizures are the most common form of childhood seizures. The exact mechanism promoting convulsions during a common febrile illness remains unknown, but it is accepted that genetic influences are likely to account for at least some of the cases. Previous studies reported high interleukin-1β levels in the cerebrospinal fluid of patients with febrile seizures. Recently, an association between a regulatory polymorphism in the genes encoding interleukin-1β and interleukin-1Ra and febrile seizures was reported. In this study, we attempted to confirm these findings. We analyzed the cytokine gene polymorphisms; of interleukin-1β, interleukin-1α, and interleukin-1Ra of 73 children with febrile seizure and 152 healthy controls. The distribution of interleukin-1β -511, interleukin-1α -889, and interleukin-1Ra genotypes and alleles did not differ significantly between cases and controls. Our data suggest that the studied gene polymorphisms of interleukin-1β, interleukin-lα, and interleukin-1Ra do not have a significant role in the pathogenesis of febrile seizures.