Follicular-fluid anti-Mullerian hormone concentrations are predictive of assisted reproduction outcome in PCOS patients

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Pabuccu R., Kaya C., Caglar G. S., Oztas E., Satiroglu H.

REPRODUCTIVE BIOMEDICINE ONLINE, vol.19, no.5, pp.631-637, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 5
  • Publication Date: 2009
  • Doi Number: 10.1016/j.rbmo.2009.06.010
  • Journal Name: REPRODUCTIVE BIOMEDICINE ONLINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.631-637
  • Kütahya Health Sciences University Affiliated: No

Abstract

Serum anti-Mullerian hormone (AM H) concentrations constitute a sensitive marker for ovarian ageing. In addition, concentrations of AMH in the follicular fluid constitute a useful marker of embryo implantation in assisted reproduction cycles. The present Study measured serum and follicular-fluid AMH concentrations on the day of oocyte retrieval. These data showed that clinical pregnancy rates (25.0, 34.1 and 42.1%, respectively, P < 0.001). embryo implantation rates (24.3, 35.0 and 44.4%, respectively, P<0.001) and fertilization rates (59.2, 70.9 and 79.5%, respectively, P < 0.001) were markedly different among the low, moderate and high follicular-fluid AMH groups but not among the different serum AMH concentration groups. Follicular-fluid AMH concentrations were negatively correlated with follicular-fluid oestradiol concentrations. The results of this study suggest that follicular-fluid AMH concentration on the day of oocyte retrieval would appear to better reflect the reproductive outcome in PCOS patients undergoing assisted reproduction.