Thiol Disulfide Homeostasis in Pseudoexfoliation Syndrome


TETİKOĞLU M., AKTAŞ S., SAĞDIK H. M. , ÖZCURA F. , UÇAR F., KOÇAK H. , ...More

CURRENT EYE RESEARCH, vol.42, no.6, pp.876-879, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.1080/02713683.2016.1256412
  • Title of Journal : CURRENT EYE RESEARCH
  • Page Numbers: pp.876-879

Abstract

Purpose: To determine the serum thiol disulfide homeostasis in patients with pseudoexfoliation (PEX) syndrome.Method: Thirty-five patients with PEX syndrome and forty healthy subjects were included in this observational case-control study. Serum native thiol, total thiol, disulfide, and native thiol/disulfide ratio were determined using a novel and automated assay.Results: The mean serum total thiol and native thiol levels were significantly lower in patients with PEX syndrome compared to healthy controls (p = 0.001). The mean serum disulfide level was significantly higher in patients with PEX syndrome compared to healthy controls (p = 0.023). The serum native thiol/disulfide ratio was lower in patients with PEX syndrome compared to healthy subjects (16 10.1 vs 22.3 +/- 11.5, respectively, p = 0.014).Conclusion: Our findings provide evidence that the dynamic native thiol/disulfide ratio is lower in PEX syndrome, which shows a reduction in the natural cell reductive capacity reservoir.