Thiol Disulfide Homeostasis in Pseudoexfoliation Syndrome
CURRENT EYE RESEARCH, vol.42, no.6, pp.876-879, 2017 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 42 Issue: 6
- Publication Date: 2017
- Doi Number: 10.1080/02713683.2016.1256412
- Journal Name: CURRENT EYE RESEARCH
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.876-879
- Keywords: Disulfide, oxidative stress, pseudoexfoliation syndrome, thiol, OXIDATIVE STRESS, AQUEOUS-HUMOR, REDOX SYSTEMS, GLUTATHIONE, LENS
- Kütahya Health Sciences University Affiliated: No
Abstract
Purpose: To determine the serum thiol disulfide homeostasis in patients with pseudoexfoliation (PEX) syndrome.Method: Thirty-five patients with PEX syndrome and forty healthy subjects were included in this observational case-control study. Serum native thiol, total thiol, disulfide, and native thiol/disulfide ratio were determined using a novel and automated assay.Results: The mean serum total thiol and native thiol levels were significantly lower in patients with PEX syndrome compared to healthy controls (p = 0.001). The mean serum disulfide level was significantly higher in patients with PEX syndrome compared to healthy controls (p = 0.023). The serum native thiol/disulfide ratio was lower in patients with PEX syndrome compared to healthy subjects (16 10.1 vs 22.3 +/- 11.5, respectively, p = 0.014).Conclusion: Our findings provide evidence that the dynamic native thiol/disulfide ratio is lower in PEX syndrome, which shows a reduction in the natural cell reductive capacity reservoir.