Effect of systemic oxytocin administration on the healing of mandibular fractures: First results

Kale Ş., Ayyıldız H., Çakır Gündoğdu A., Altay B.

AÇBİD 16th INTERNATIONAL CONGRESS-AsianAOMS 2023, Antalya, Turkey, 10 - 14 May 2023, no.35, pp.42

  • Publication Type: Conference Paper / Summary Text
  • City: Antalya
  • Country: Turkey
  • Page Numbers: pp.42
  • Kütahya Health Sciences University Affiliated: Yes


Objective: Mandible fractures are the most commonly treated fracture types by maxillofacial surgeons. Accelerating the healing of mandible fractures will provide patients with faster functional recovery in terms of temporomandibular joint disorders, malnutrition and periodontal problems. Reducing the healing time in the treatment of these fractures has recently become an important issue. In this experimental study, the effects of oxytocin on the mandibular fracture in rats at 3 different healing stages were evaluated. Materials-Methods: This experimental study was conducted on 42 male wistar albino rats. In our study, control and experimental groups were planned to perform sacrification on the 10th, 20th and 30th days to evaluate the different bone healing stages. Therefore, 3 experimental and 3 control groups were formed in the study. 10 μIU/kg of systemic oxytocin was administered daily to all experimental groups. Densitometric results at the fracture line were evaluated on periapical radiographs. Results: The mean bone gray value of the mice in the control groups was 0.87. The mean bone gray value of the mice in the experimental groups was 1.25. The difference between the mean bone gray value of these groups was statistically significant. Conclusion: Oxytocin increases osteoblast differentiation and function, resulting in increased bone formation. Studies have shown that treatment with oxytocin causes an increase in intracellular calcium levels and regulates the stimulation of osteoblast formation and thus bone formation in rats. In our study, the bone gray value at the fracture line was found to be significantly higher in the groups administered oxytocin. Keywords: mandibular fracture, oxytocin