AÇBİD 16th INTERNATIONAL CONGRESS-AsianAOMS 2023, Antalya, Turkey, 10 - 14 May 2023, no.35, pp.42
Objective: Mandible fractures are the most commonly treated fracture types by maxillofacial
surgeons. Accelerating the healing of mandible fractures will provide patients with faster
functional recovery in terms of temporomandibular joint disorders, malnutrition and periodontal
problems. Reducing the healing time in the treatment of these fractures has recently become
an important issue. In this experimental study, the effects of oxytocin on the mandibular
fracture in rats at 3 different healing stages were evaluated.
Materials-Methods: This experimental study was conducted on 42 male wistar albino rats. In
our study, control and experimental groups were planned to perform sacrification on the 10th,
20th and 30th days to evaluate the different bone healing stages. Therefore, 3 experimental
and 3 control groups were formed in the study. 10 μIU/kg of systemic oxytocin was administered
daily to all experimental groups. Densitometric results at the fracture line were evaluated on
Results: The mean bone gray value of the mice in the control groups was 0.87. The mean
bone gray value of the mice in the experimental groups was 1.25. The difference between the
mean bone gray value of these groups was statistically significant.
Conclusion: Oxytocin increases osteoblast differentiation and function, resulting in increased
bone formation. Studies have shown that treatment with oxytocin causes an increase in
intracellular calcium levels and regulates the stimulation of osteoblast formation and thus
bone formation in rats. In our study, the bone gray value at the fracture line was found to be
significantly higher in the groups administered oxytocin.
Keywords: mandibular fracture, oxytocin