Acute fluconazole toxicity: a case presenting with protean manifestations including systemic and neurologic symptoms

Eskut N., Gedizlioglu M., Unal O., Ozlu C., Ergene U.

POSTGRADUATE MEDICINE, vol.133, no.2, pp.250-252, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 133 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.1080/00325481.2020.1840830
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, CINAHL, EBSCO Education Source, Educational research abstracts (ERA), EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.250-252
  • Keywords: acute renal insufficiency, adverse reactions, Fluconazole, polyneuropathy, thrombotic thrombocytopenic purpura
  • Kütahya Health Sciences University Affiliated: Yes


Neurologic adverse effects of triazole antifungal compounds used for the treatment of systemic and deep mycoses are relatively rare. The most common presentation is the involvement of peripheral nervous system, usually presenting with subjective symptoms such as paresthesia, dysesthesia, or numbness. Among these compounds, fluconazole has relatively more frequent neurological adverse reactions.