Synthesis of cyclopentapyridine and thienopyridine derivatives as potential calcium channel modulators
Arzneimittel-Forschung/Drug Research, cilt.62, sa.4, ss.167-175, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 62 Sayı: 4
- Basım Tarihi: 2012
- Doi Numarası: 10.1055/s-0031-1299744
- Dergi Adı: Arzneimittel-Forschung/Drug Research
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.167-175
- Anahtar Kelimeler: 1,4-Dihydropyridine, calcium channel modulator, cyclopentapyridine, thienopyridine
- Kütahya Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
In this study, novel condensed 1,4-dihydropyridines bearing cyclopentanone (1-21) or tetrahydrothiophene-1,1-dioxide ring (22-42) with various ester substituents were synthesized via a modified Hantzsch reaction and their calcium channel modulator activities were investigated on isolated rat ileum and rat thoracic aorta. The introduction of a cyclopentanone ring fused to the 1,4-dihydropyridine nucleus and methyl, ethyl and allyl moieties to the ester group led to more active calcium modulators. © Georg Thieme Verlag KG Stuttgart · New York.