Effects of lornoxicam and intravenous ibuprofen on erythrocyte deformability and hepatic and renal blood flow in rats

ARPACI A. H. , ÇOMU F. M. , KÜÇÜK A. , KÖSEM B., KARTAL S., ŞIVGIN V., ...Daha Fazla

Drug Design Development and Therapy, cilt.10, ss.2477-2481, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10
  • Basım Tarihi: 2016
  • Doi Numarası: 10.2147/dddt.s113806
  • Dergi Adı: Drug Design Development and Therapy
  • Sayfa Sayıları: ss.2477-2481


Background: Change in blood supply is held responsible for anesthesia-related abnormal tissue and organ perfusion. Decreased erythrocyte deformability and increased aggregation may be detected after surgery performed under general anesthesia. It was shown that nonsteroidal anti-inflammatory drugs decrease erythrocyte deformability. Lornoxicam and/or intravenous (iv) ibuprofen are commonly preferred analgesic agents for postoperative pain management. In this study, we aimed to investigate the effects of lornoxicam (2 mg/kg, iv) and ibuprofen (30 mg/kg, iv) on erythrocyte deformability, as well as hepatic and renal blood flows, in male rats.