Effects of lornoxicam and intravenous ibuprofen on erythrocyte deformability and hepatic and renal blood flow in rats


ARPACI A. H. , ÇOMU F. M. , KÜÇÜK A. , KÖSEM B., KARTAL S., ŞIVGIN V., ...More

Drug Design Development and Therapy, vol.10, pp.2477-2481, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10
  • Publication Date: 2016
  • Doi Number: 10.2147/dddt.s113806
  • Title of Journal : Drug Design Development and Therapy
  • Page Numbers: pp.2477-2481
  • Keywords: rat, lornoxicam, iv ibuprofen, erythrocyte deformability, blood flow, ISCHEMIA-REPERFUSION INJURY, HYPERTENSION, CELL

Abstract

Background: Change in blood supply is held responsible for anesthesia-related abnormal tissue and organ perfusion. Decreased erythrocyte deformability and increased aggregation may be detected after surgery performed under general anesthesia. It was shown that nonsteroidal anti-inflammatory drugs decrease erythrocyte deformability. Lornoxicam and/or intravenous (iv) ibuprofen are commonly preferred analgesic agents for postoperative pain management. In this study, we aimed to investigate the effects of lornoxicam (2 mg/kg, iv) and ibuprofen (30 mg/kg, iv) on erythrocyte deformability, as well as hepatic and renal blood flows, in male rats.