Synthesis, characterization, and pharmacological evaluation of the proton transfer salts of 2-aminobenzothiazole derivatives with 5-sulfosalicylic acid and their Cu(II) complexes


Ilkimen H., Teksen Y. , Yenikaya C., Turhan I., Tunc T., Sari M.

JOURNAL OF COORDINATION CHEMISTRY, cilt.71, ss.2831-2842, 2018 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 71
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1080/00958972.2018.1504035
  • Dergi Adı: JOURNAL OF COORDINATION CHEMISTRY
  • Sayfa Sayısı: ss.2831-2842

Özet

Two proton transfer compounds, formed between 2-aminobenzothiazole derivatives (2-aminobenzothiazole (abt) and 2-amino-6-ethoxybenzothiazole (EtOabt)) and 5-sulfosalicylic acid dihydrate (H3ssa) as parent compounds, (Habt)(+) (H2ssa)(-) (1) and (HEtOabt)(+) (H2ssa)(-) (2) and their Cu(II) complexes (3 and 4, respectively) have been prepared and characterized using spectroscopic techniques. The single crystal X-ray diffraction method has been also applied to 3 and 4. Although 3 has a distorted octahedral form, 4 exhibits a distorted square pyramidal geometry. All compounds, including saline and diclofenac sodium as standards, have been evaluated pharmacologically for their anti-inflammatory and analgesic activities in rats and mice. Parent compounds (abt, EtOabt, and H3ssa) 3 and 4 showsignificant anti-inflammatory and analgesic activities as compared with control compounds.