INTERNATIONAL UROLOGY AND NEPHROLOGY, vol.48, no.3, pp.441-450, 2016 (Journal Indexed in SCI)
Article / Article
Title of Journal :
INTERNATIONAL UROLOGY AND NEPHROLOGY
Diabetic nephropathy, Ozone therapy, Caspase, HIF-1 alpha, TNF-alpha, TUBULAR EPITHELIAL-CELLS, OXIDATIVE STRESS, ISCHEMIA-REPERFUSION, INDUCED APOPTOSIS, RAT-KIDNEY, EXPRESSION, GLUCOSE, INJURY, HYPOXIA, ACTIVATION
Accelerated apoptosis plays a vital role in the development of diabetic vascular complications. Ozone may attenuate diabetic nephropathy by means of decreased apoptosis-related genes. The aim of our study was to investigate the effect of ozone therapy on streptozotocin-induced diabetic nephropathy in rats. Also the histopathological changes in diabetic kidney tissue with ozone treatment were evaluated.