The effects of ozone therapy on caspase pathways, TNF-alpha, and HIF-1 alpha in diabetic nephropathy


Güçlü A., Erken H. A. , Erken G., Dodurga Y., Yay A. H. , Özçoban Ö., et al.

INTERNATIONAL UROLOGY AND NEPHROLOGY, cilt.48, ss.441-450, 2016 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 48 Konu: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s11255-015-1169-8
  • Dergi Adı: INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Sayfa Sayısı: ss.441-450

Özet

Accelerated apoptosis plays a vital role in the development of diabetic vascular complications. Ozone may attenuate diabetic nephropathy by means of decreased apoptosis-related genes. The aim of our study was to investigate the effect of ozone therapy on streptozotocin-induced diabetic nephropathy in rats. Also the histopathological changes in diabetic kidney tissue with ozone treatment were evaluated.