The effects of ozone therapy on caspase pathways, TNF-alpha, and HIF-1 alpha in diabetic nephropathy


Güçlü A., Erken H. A. , Erken G., Dodurga Y., Yay A. H. , Özçoban Ö., ...More

INTERNATIONAL UROLOGY AND NEPHROLOGY, vol.48, no.3, pp.441-450, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.1007/s11255-015-1169-8
  • Title of Journal : INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Page Numbers: pp.441-450
  • Keywords: Diabetic nephropathy, Ozone therapy, Caspase, HIF-1 alpha, TNF-alpha, TUBULAR EPITHELIAL-CELLS, OXIDATIVE STRESS, ISCHEMIA-REPERFUSION, INDUCED APOPTOSIS, RAT-KIDNEY, EXPRESSION, GLUCOSE, INJURY, HYPOXIA, ACTIVATION

Abstract

Accelerated apoptosis plays a vital role in the development of diabetic vascular complications. Ozone may attenuate diabetic nephropathy by means of decreased apoptosis-related genes. The aim of our study was to investigate the effect of ozone therapy on streptozotocin-induced diabetic nephropathy in rats. Also the histopathological changes in diabetic kidney tissue with ozone treatment were evaluated.