Some pyridazinone and phthalazinone derivatives and their vasodilator activities
Archives of Pharmacal Research, cilt.27, sa.1, ss.13-18, 2004 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27 Sayı: 1
- Basım Tarihi: 2004
- Doi Numarası: 10.1007/bf02980038
- Dergi Adı: Archives of Pharmacal Research
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.13-18
- Anahtar Kelimeler: Phthalazinone, Pyridazinone, Vasodilator activity
- Kütahya Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
In this study, 6-[(4-arylidene-2-phenyl-5-oxoimidazolin-1-yl)phenyl]-4,5- dihydro-3(2H)-pyridazinone and 4-[(4-arylidene-2-phenyl-5-oxoimidazolin-1-yl) phenyl]-1(2H)-phthalazinone derivatives were synthesized by reacting 6-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone or 4-(4-aminophenyl)-1(2H)- phthalazinone compound with different 4-arylidene-2-phenyl-5(4H)-oxazolone derivatives. The vasodilator activities of the compounds were examined both in vitro and in vivo. Some pyridazinone derivatives showed appreciable activity.