Association between well-known histopathological criteria and overall survival in invasive ductal carcinoma


DEĞER A. N. , Özyiğit F. , ARIK Ö. , ekici f. , Cinkaya A., TAYFUR M., ...More

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, vol.8, no.9, pp.9772-9781, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 9
  • Publication Date: 2015
  • Title of Journal : INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
  • Page Numbers: pp.9772-9781

Abstract

We investigated the effect of clinical features and well-known histomorphological parameters on survival of breast cancer. Material and methods: 44 patients with invasive ductal carcinoma were included in this study. We investigated the effect of age, breast cancer location (right/left), histological grade, largest diameter of the tumor, lymphovascular and perineural invasion on patient survival. IBM SPSS (Statistical Package for Social Sciences) 20 program was used for statistics. Cox proportional hazard regression model for survival analysis, log-log plot, life function graphs were used. Results were 95% confidence interval, significance (P < 0.05). Results: In univariate analysis, the left breast localization, high histological grade, large tumor size, lymphovascular invasion, perineural invasion has been shown that reduced the overall survival (P < 0.05). In multivariate analysis, only high histological grade, large tumor size and perineural invasion were identified as parameters negatively associated with patient survival (P < 0.05). On univariate and multivariate analysis, age was not associated with survival. Conclusion: The above results should be considered in the follow-up and treatment planning of invasive ductal carcinoma patients.