Repeated Doses of Ketamine Affect the Infant Rat Urogenital System


Kasikara H., Sungu N., ARSLAN M., KÜÇÜK A. , Ozturk L., Afandiyeva N., ...More

DRUG DESIGN DEVELOPMENT AND THERAPY, vol.15, pp.1157-1165, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15
  • Publication Date: 2021
  • Doi Number: 10.2147/dddt.s285862
  • Title of Journal : DRUG DESIGN DEVELOPMENT AND THERAPY
  • Page Numbers: pp.1157-1165
  • Keywords: ketamine, infant rat, testicular tissue, kidney, epididymis

Abstract

Aim: Long-term ketamine use is known to create an interstitial cystitis-like problem in the bladder. It is known that long-term intermittent ketamine is applied to the children receiving radiotherapy for sedation. This study was planned to investigate whether this effect seen in the bladder causes similar changes in the kidneys, testicles, epididymis and ductus deferens.