Repeated Doses of Ketamine Affect the Infant Rat Urogenital System

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Kasikara H., Sungu N., ARSLAN M., KÜÇÜK A., Ozturk L., Afandiyeva N., ...More

DRUG DESIGN DEVELOPMENT AND THERAPY, vol.15, pp.1157-1165, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15
  • Publication Date: 2021
  • Doi Number: 10.2147/dddt.s285862
  • Journal Name: DRUG DESIGN DEVELOPMENT AND THERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, EMBASE, MEDLINE, Directory of Open Access Journals
  • Page Numbers: pp.1157-1165
  • Keywords: ketamine, infant rat, testicular tissue, kidney, epididymis
  • Kütahya Health Sciences University Affiliated: Yes

Abstract

Aim: Long-term ketamine use is known to create an interstitial cystitis-like problem in the bladder. It is known that long-term intermittent ketamine is applied to the children receiving radiotherapy for sedation. This study was planned to investigate whether this effect seen in the bladder causes similar changes in the kidneys, testicles, epididymis and ductus deferens.