Human & Experimental Toxicology, vol.40, no.9, pp.1572-1583, 2021 (SCI-Expanded)
Background: Hexagonal boron nitride nanoparticles (hBN NPs) are encouraging nanomaterials with unique
chemical properties in medicine and biomedical fields. Until now, the optimal hBN NP’s dosage and biochemical
mechanism that can be used for in vivo systems has not been fully revealed. The main aim of this article is to
reveal characteristics, serum and tissue interactions and any acute cytotoxic effect of different dose of hBN
NPs for the first time.
Methods: hBN NPs at concentrations varying between 50–3200 mg/kg was administered by intravenous
injection to Wistar albino rats (n ¼ 80) divided into seven dosage and control groups. Blood and tissue samples
were taken after 24 hours.
Results: Our findings suggested that higher doses hBN NPs caused oxidative stress on the serum of rats dosedependently.
However, hBN NPs did not affect thiol/disulfide homeostasis on kidney, liver, spleen, pancreas and
heart tissue of rats. Furthermore, hBN NPs increased serum disulfide formation by disrupting the thiol/disulfide
balance in rats. Also, LOOH and MPO levels increased at high doses, while CAT levels decreased statistically.
Conclusion: The results revealed that hBN NPs induce oxidative stress in a dose-dependent manner by
modulating thiol/disulfide homeostasis in rats at higher concentrations